Effect of Apremilast on LPS-induced immunomodulation and inflammation via activation of Nrf2/HO-1 pathways in rat lungs

Effect of Apremilast on LPS-induced immunomodulation and inflammation via activation of Nrf2/HO-1 pathways in rat lungs

Lipopolysaccharides (LPS), the lipid component of gram-negative bacterial cell wall, is recognized as the key factor in acute lung inflammation and is found to exhibit severe immunologic reactions. Phosphodiesterase-4 (PDE-4) inhibitor: “apremilast (AP)” is an immune suppressant and anti-inflammator...

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Bibliographic Details
Main Authors: Naif O. Al-Harbi, Faisal Imam, Mohammad Matar Al-Harbi, Wajhul Qamar, Khaldoon Aljerian, Md. Khalid Anwer, Mohammed Alharbi, Sultan Almudimeegh, Abdullah S. Alhamed, Ali A Alshamrani
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Saudi Pharmaceutical Journal
Subjects:
Apremilast
Lipopolysaccharides
Heme-oxygenase
Nitric oxide synthase-2
Western blot
Polymerase chain reaction
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016423001482

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http://www.sciencedirect.com/science/article/pii/S1319016423001482

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