Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling

Pharmacological activation of PPARβ/δ preserves mitochondrial respiratory function in ischemia/reperfusion via stimulation of fatty acid oxidation-linked respiration and PGC-1α/NRF-1 signaling

Myocardial ischemia/reperfusion (I/R) injury leads to significant impairment of cardiac function and remains the leading cause of morbidity and mortality worldwide. Activation of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) confers cardioprotection via pleiotropic effects including antio...

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Bibliographic Details
Main Authors: Ioanna Papatheodorou, Marina Makrecka-Kuka, Janis Kuka, Edgars Liepinsh, Maija Dambrova, Antigone Lazou
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Endocrinology
Subjects:
ischemia/reperfusion
cardioprotection
electron transport system
fatty acid oxidation
mitochondrial respiration
ROS
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.941822/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.941822/full

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