High Stromal SFRP2 Expression in Urothelial Carcinoma Confers an Unfavorable Prognosis

High Stromal SFRP2 Expression in Urothelial Carcinoma Confers an Unfavorable Prognosis

BackgroundUrothelial carcinoma (UC) patients often bear clinical and genetic heterogeneity, which may differ in management and prognosis. Especially, patients with advanced/metastatic UC generally have a poor prognosis and survive for only few months. The Wnt/β-catenin signaling is found to be highl...

Full description

Bibliographic Details
Main Authors:	Hong-Yue Lai, Chia-Chun Chiu, Yu-Hsuan Kuo, Hsin-Hwa Tsai, Li-Ching Wu, Wen-Hsin Tseng, Chien-Liang Liu, Chung-Hsi Hsing, Steven K. Huang, Chien-Feng Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-03-01
Series:	Frontiers in Oncology
Subjects:	urothelial carcinoma bladder cancer upper urinary tract cancer SFRP2 collagen stroma
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2022.834249/full

Similar Items

Overexpression of Pyruvate Dehydrogenase Kinase-3 Predicts Poor Prognosis in Urothelial Carcinoma
by: Yu-Hsuan Kuo, et al.
Published: (2021-09-01)

Low expression of ZSCAN4 predicts unfavorable outcome in urothelial carcinoma of upper urinary tract and urinary bladder
by: Hong-Lin He, et al.
Published: (2023-02-01)

Angiogenesis Driven by the CEBPD–hsa-miR-429–VEGFA Signaling Axis Promotes Urothelial Carcinoma Progression
by: Ti-Chun Chan, et al.
Published: (2022-02-01)

The biological impacts of CEBPD on urothelial carcinoma development and progression
by: Ti-Chun Chan, et al.
Published: (2023-01-01)

Upregulation of dihydropyrimidinase-like 3 (DPYSL3) protein predicts poor prognosis in urothelial carcinoma
by: Peir-In Liang, et al.
Published: (2023-06-01)

Prognostic Utility of FBLN2 Expression in Patients With Urothelial Carcinoma
by: Wei-Ming Li, et al.
Published: (2020-10-01)

Uncovering the Inhibitory Molecular Mechanism of Pomegranate Peel to Urinary Bladder Urothelial Carcinoma Using Proteomics Techniques
by: Kuan-Hua Huang, et al.
Published: (2022-11-01)

Metformin Resensitizes Sorafenib-Resistant HCC Cells Through AMPK-Dependent Autophagy Activation
by: Hong-Yue Lai, et al.
Published: (2021-01-01)

HuR cytoplasmic expression is associated with increased cyclin A expression and poor outcome with upper urinary tract urothelial carcinoma
by: Liang Peir-In, et al.
Published: (2012-12-01)

The association between gender and outcome of patients with upper tract urothelial cancer
by: Yii-Her Chou, et al.
Published: (2013-01-01)

Downregulation of CRTAC1 in Urothelial Carcinoma Promotes Tumor Aggressiveness and Confers Poor Prognosis
by: Wei-Ming Li, et al.
Published: (2023-09-01)

Study of SFRP1 and SFRP2 methylation status in patients with de novo Acute Myeloblastic Leukemia
by: Ali Ghasemi, et al.
Published: (2015-03-01)

Prognostic Significance of ROR2 Expression in Patients with Urothelial Carcinoma
by: Cheng-Fa Yeh, et al.
Published: (2021-08-01)

The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt/β-catenin signaling pathway
by: Mei Yang, et al.
Published: (2023-03-01)

Metformin is associated with better survival rate of localized upper tract urothelial carcinoma patients with type 2 diabetes
by: Chung-Yu Lin, et al.
Published: (2023-01-01)

Interleukin-19 in Breast Cancer
by: Ying-Yin Chen, et al.
Published: (2013-01-01)

Inhibiting interleukin-19 activity ameliorates esophageal squamous cell carcinoma progression.
by: Chung-Hsi Hsing, et al.
Published: (2013-01-01)

The Association Between Renal Function Decline and the Incidence of Urothelial Carcinoma: A 16-year Retrospective Cohort Study in Taiwan
by: Yung-Hsin Chuang, et al.
Published: (2021-05-01)

The role of Sfrp and DKK proteins in cardiomyocyte development
by: Ying‐Chang Hsueh, et al.
Published: (2021-02-01)

Overexpression of PTP4A3 is associated with metastasis and unfavorable prognosis in urothelial carcinoma
by: Hsin-Chih Yeh, et al.
Published: (2016-06-01)

Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2
by: Haili Bao, et al.
Published: (2020-10-01)

High SPINK4 Expression Predicts Poor Outcomes among Rectal Cancer Patients Receiving CCRT
by: Tzu-Ju Chen, et al.
Published: (2021-06-01)

Navigating the obesity paradox in bladder cancer prognosis—insights from the Taiwan National Health Insurance System Database
by: Wen-Hsin Tseng, et al.
Published: (2024-12-01)

Central pathology review and its prognostic value in upper tract urothelial carcinoma patients: a nationwide multi-institutional study
by: Yung-Tai Chen, et al.
Published: (2024-08-01)

CTSE Overexpression Is an Adverse Prognostic Factor for Survival among Rectal Cancer Patients Receiving CCRT
by: Chia-Lin Chou, et al.
Published: (2021-07-01)

Efficacy of the intracorporeal one-hand tie technique for renal pedicle control during hand-assisted retroperitoneoscopic nephroureterectomy
by: Chien-Hui Ou, et al.
Published: (2015-12-01)

MiR-1180 from bone marrow MSCs promotes cell proliferation and glycolysis in ovarian cancer cells via SFRP1/Wnt pathway
by: Jinghui Hu, et al.
Published: (2019-03-01)

Association between the neutrophil-to-lymphocyte ratio and cognitive impairment: a meta-analysis of observational studies
by: Kuo-Chuan Hung, et al.
Published: (2023-11-01)

The Significant Prognosticators of Upper Tract Urothelial Carcinoma
by: Tsu-Ming Chien, et al.
Published: (2015-12-01)

SFRP1, Posible biomarcador en la progresión o regresión de lesiones de cérvix asociado al Virus del Papiloma Humano
by: Juvenal Darío Baena-Acevedo
Published: (2021-04-01)

Conservative management of upper tract urothelial carcinoma with endoscopic thulium laser ablation: A retrospective study with subgroup analyses
by: Yu-Che Hsieh, et al.
Published: (2020-01-01)

Determination of SFRP1 and SFRP2 Genes Promoter Methylation Status in Patients with Chronic Myelogenous Leukemia
by: Elahe Derakhshanfar, et al.
Published: (2017-03-01)

scRNA-seq characterizing the heterogeneity of fibroblasts in breast cancer reveals a novel subtype SFRP4+ CAF that inhibits migration and predicts prognosis
by: Lvwen Ning, et al.
Published: (2024-04-01)

Study of SFRP1 and SFRP2 Genes Methylation Status in Patients with De Novo Acute Myeloblastic Leukemia
by: Ali Ghasemi, et al.
Published: (2014-07-01)

SFRP1 induces a stem cell phenotype in prostate cancer cells
by: Alberto Losada-García, et al.
Published: (2023-03-01)

SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells
by: Elif Akova Ölken, et al.
Published: (2022-12-01)

Epigenetic loss of putative tumor suppressor SFRP3 correlates with poor prognosis of lung adenocarcinoma patients
by: Martin Schlensog, et al.
Published: (2018-03-01)

Biological significance of MYC and CEBPD coamplification in urothelial carcinoma: Multilayered genomic, transcriptional and posttranscriptional positive feedback loops enhance oncogenic glycolysis
by: Ti‐Chun Chan, et al.
Published: (2021-12-01)

Identification of potential genes in upper tract urothelial carcinoma using next-generation sequencing with bioinformatics and in vitro analyses
by: Hsiang-Ying Lee, et al.
Published: (2021-04-01)

Re: Outcome of second-look transurethral resection of bladder tumors for T1 bladder cancer: A five-year
by: Wen-Hsin Tseng, et al.
Published: (2018-01-01)