Bifidobacterium dentium-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation

Bifidobacterium dentium-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation

Endoplasmic reticulum (ER) stress compromises the secretion of MUC2 from goblet cells and has been linked with inflammatory bowel disease (IBD). Although Bifidobacterium can beneficially modulate mucin production, little work has been done investigating the effects of Bifidobacterium on goblet cell...

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Bibliographic Details
Main Authors: Melinda A. Engevik, Beatrice Herrmann, Wenly Ruan, Amy C. Engevik, Kristen A. Engevik, Faith Ihekweazu, Zhongcheng Shi, Berkley Luck, Alexandra L. Chang-Graham, Magdalena Esparza, Susan Venable, Thomas D. Horvath, Sigmund J. Haidacher, Kathleen M. Hoch, Anthony M. Haag, Deborah A. Schady, Joseph M. Hyser, Jennifer K. Spinler, James Versalovic
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Gut Microbes
Subjects:
muc2
goblet cells
bifidobacteria
er-stress
organoids
il-10
colitis
ibd
Online Access:http://dx.doi.org/10.1080/19490976.2021.1902717

Internet

http://dx.doi.org/10.1080/19490976.2021.1902717

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