The effects of enhancing angiotensin converting enzyme in myelomonocytes on ameliorating Alzheimer’s-related disease and preserving cognition

The effects of enhancing angiotensin converting enzyme in myelomonocytes on ameliorating Alzheimer’s-related disease and preserving cognition

This review examines the role of angiotensin-converting enzyme (ACE) in the context of Alzheimer’s disease (AD) and its potential therapeutic value. ACE is known to degrade the neurotoxic 42-residue long alloform of amyloid β-protein (Aβ42), a peptide strongly associated with AD. Previous studies in...

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Bibliographic Details
Main Authors: Ron Danziger, Dieu-Trang Fuchs, Yosef Koronyo, Altan Rentsendorj, Julia Sheyn, Eric Y. Hayden, David B. Teplow, Keith L. Black, Sebastien Fuchs, Kenneth E. Bernstein, Maya Koronyo-Hamaoui
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Physiology
Subjects:
microglia
monocytes
macrophages
innate immune cells
degrading peptidase
pro-inflammatory cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1179315/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1179315/full

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