A retrospective analysis of conditional power assumptions in clinical trials with continuous or binary endpoints

Abstract Background Adaptive clinical trials may use conditional power (CP) to make decisions at interim analyses, requiring assumptions about the treatment effect for remaining patients. It is critical that these assumptions are understood by those using CP in decision-making, as well as timings of...

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Bibliographic Details
Main Authors: Julia M. Edwards, Stephen J. Walters, Steven A. Julious
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Trials
Subjects:
Online Access:https://doi.org/10.1186/s13063-023-07202-6