Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress

Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress

Abstract Background Metabolic adaptations can allow cancer cells to survive DNA-damaging chemotherapy. This unmet clinical challenge is a potential vulnerability of cancer. Accordingly, there is an intense search for mechanisms that modulate cell metabolism during anti-tumor therapy. We set out to d...

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Bibliographic Details
Main Authors: Christian Marx, Jürgen Sonnemann, Oliver D. K. Maddocks, Lisa Marx-Blümel, Mandy Beyer, Doerte Hoelzer, René Thierbach, Claudia Maletzki, Michael Linnebacher, Thorsten Heinzel, Oliver H. Krämer
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Cancer & Metabolism
Subjects:
Adaptation
Colorectal cancer
Glucose
Irinotecan
Metabolism
p53
Online Access:https://doi.org/10.1186/s40170-022-00286-9

Internet

https://doi.org/10.1186/s40170-022-00286-9

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