Beta human papillomavirus 8E6 promotes alternative end joining

Beta human papillomavirus 8E6 promotes alternative end joining

Double strand breaks (DSBs) are one of the most lethal DNA lesions in cells. The E6 protein of beta-human papillomavirus (HPV8 E6) impairs two critical DSB repair pathways: homologous recombination (HR) and non-homologous end joining (NHEJ). However, HPV8 E6 only delays DSB repair. How DSBs are repa...

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Bibliographic Details
Main Authors: Changkun Hu, Taylor Bugbee, Rachel Palinski, Ibukun A Akinyemi, Michael T McIntosh, Thomas MacCarthy, Sumita Bhaduri-McIntosh, Nicholas Wallace
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
beta-HPV
DSB repair
MMEJ
P300
NHEJ
HR
Online Access:https://elifesciences.org/articles/81923

Internet

https://elifesciences.org/articles/81923

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