Intra- and inter-tumor heterogeneity of BRAF(V600E))mutations in primary and metastatic melanoma.

Intra- and inter-tumor heterogeneity of BRAF(V600E))mutations in primary and metastatic melanoma.

The rationale for using small molecule inhibitors of oncogenic proteins as cancer therapies depends, at least in part, on the assumption that metastatic tumors are primarily clonal with respect to mutant oncogene. With the emergence of BRAF(V600E) as a therapeutic target, we investigated intra- and...

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Bibliographic Details
Main Authors: Molly Yancovitz, Adam Litterman, Joanne Yoon, Elise Ng, Richard L Shapiro, Russell S Berman, Anna C Pavlick, Farbod Darvishian, Paul Christos, Madhu Mazumdar, Iman Osman, David Polsky
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3250426?pdf=render

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http://europepmc.org/articles/PMC3250426?pdf=render

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