Phosphoglycerate mutase 5 exacerbates liver ischemia–reperfusion injury by activating mitochondrial fission

Abstract Although the death of hepatocytes is a crucial trigger of liver ischemia–reperfusion (I/R) injury, the regulation of liver I/R-induced hepatocyte death is still poorly understood. Phosphoglycerate mutase 5 (PGAM5), a mitochondrial Serine/Threonine protein phosphatase, regulates mitochondria...

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Bibliographic Details
Main Authors: Hongwei Tang, Qiwen Yu, Xu Chen, Jiakai Zhang, Danfeng Guo, Wenzhi Guo, Shuijun Zhang, Xiaoyi Shi
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Online Access:https://doi.org/10.1038/s41598-024-58748-7