Extracellular Matrix-Induced GM-CSF and Hypoxia Promote Immune Control of Mycobacterium tuberculosis in Human In Vitro Granulomas

Extracellular Matrix-Induced GM-CSF and Hypoxia Promote Immune Control of Mycobacterium tuberculosis in Human In Vitro Granulomas

Several in vitro cellular models have been developed with the aim to reproduce and dissect human granulomatous responses, the hallmark of tuberculosis (TB) immunopathogenesis. In that context, we compared two- (2D) versus three-dimensional (3D) granuloma models resulting from infection of human peri...

Full description

Bibliographic Details
Main Authors: Ainhoa Arbués, Sarah Schmidiger, Michael Kammüller, Damien Portevin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Immunology
Subjects:
tuberculosis
granuloma
extracellular matrix
GM-CSF (granulocyte-macrophage colony-stimulating factor)
hypoxia
in vitro model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.727508/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.727508/full

Similar Items