The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage

The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage

The replication and pathogenicity of SARS-CoV-2 Omicron BA.2 are comparable to that of BA.1 in experimental animal models. However, BA.2 has rapidly emerged to overtake BA.1 to become the predominant circulating SARS-CoV-2 variant worldwide. Here, we compared the replication fitness of BA.1 and BA.2...

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Bibliographic Details
Main Authors: Ronghui Liang, Zi-Wei Ye, Chon Phin Ong, Zhenzhi Qin, Yubin Xie, Yilan Fan, Kaiming Tang, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Xiaomeng Yang, Hehe Cao, Kun Wang, Haoran Sun, Bodan Hu, Jian-Piao Cai, Cuiting Luo, Kenn Ka-Heng Chik, Hin Chu, Yi Zheng, Kwok-Yung Yuen, Jasper Fuk-Woo Chan, Dong-Yan Jin, Shuofeng Yuan
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Emerging Microbes and Infections
Subjects:
COVID-19
Omicron BA.1
Omicron BA.2
fitness
G496S
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2022.2111977

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2022.2111977

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