Felodipine attenuates neuroinflammatory responses and tau hyperphosphorylation through JNK/P38 signaling in tau-overexpressing AD mice

Felodipine attenuates neuroinflammatory responses and tau hyperphosphorylation through JNK/P38 signaling in tau-overexpressing AD mice

Abstract We previously demonstrated that felodipine, an L-type calcium channel blocker, inhibits LPS-mediated neuroinflammatory responses in BV2 microglial cells and wild-type mice. However, the effects of felodipine on tau pathology, a hallmark of Alzheimer's disease (AD), have not been explor...

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Bibliographic Details
Main Authors: Jeong-Woo Hwang, Jeongha Kim, Jin-Hee Park, Jinhan Nam, Ji-Yeong Jang, Aran Jo, Hyun-ju Lee, Hyang-Sook Hoe
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Molecular Brain
Subjects:
Felodipine
Neuroinflammation
Tau
Microgliosis
Alzheimer's disease
Online Access:https://doi.org/10.1186/s13041-024-01137-y

Internet

https://doi.org/10.1186/s13041-024-01137-y

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