p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms.

p57Kip2 is an essential regulator of vitamin D receptor-dependent mechanisms.

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A cyclin-dependent kinase (CDK) inhibitor, p57Kip2, is an important molecule involved in bone development; p57Kip2-deficient (p57-/-) mice display neonatal lethality resulting from abnormal bone formation and cleft palate. The modulator 1α,25-dihydroxyvitamin D3 (l,25-(OH)2VD3) has shown the potenti...

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Bibliographic Details
Main Authors: Katsuhiko Takahashi, Hitoshi Amano, Tomohiko Urano, Minqi Li, Meiko Oki, Kazuhiro Aoki, Norio Amizuka, Keiichi I Nakayama, Keiko Nakayama, Nobuyuki Udagawa, Nobuaki Higashi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0276838

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https://doi.org/10.1371/journal.pone.0276838

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