Extracellular vesicle-associated microRNA-30b-5p activates macrophages through the SIRT1/ NF-κB pathway in cell senescence

Extracellular vesicle-associated microRNA-30b-5p activates macrophages through the SIRT1/ NF-κB pathway in cell senescence

Chronic inflammation is widely observed in aging, but it is unclear whether extracellular vesicles (EVs) play a role in chronic disease-associated senescence. In our study, LC/MS profiling revealed that senescent cell derived EVs (SEN EVs) activate the immune response pathways of macrophages. Signif...

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Bibliographic Details
Main Authors: Yu Xiao, Jiaqi Liang, Kenneth W. Witwer, Ying Zhang, Qian Wang, Hang Yin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
extracellular vesicles
miRNA
SIRT1
cell senescence
NF-κB
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.955175/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.955175/full

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