In Vitro Hb Production in Β-thalassemia Patients Is Not a Predictor of Clinical Responsiveness to Hydroxyurea

Background: The hematologic response to hydroxyurea (HU) is varied among β-thalassemia (BT) patients. The BCL11A and SOX6 genes are involved in response to HU. This study aimed to investigate the in-vitro responsiveness of HU among BT major patients homozygote for IVSII-1G>A mutation and XmnI sin...

Full description

Bibliographic Details
Main Authors: Mohammad Reza MAHDAVI, Farzin POURFARZAD, Mehrnoush KOSARYAN, Mohammad Taghi AKBARI
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2017-06-01
Series:Iranian Journal of Public Health
Subjects:
Online Access:https://ijph.tums.ac.ir/index.php/ijph/article/view/10395