Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of the <i>Ube3a</i> Gene

Generation and Characterization of a Novel Angelman Syndrome Mouse Model with a Full Deletion of the <i>Ube3a</i> Gene

Angelman syndrome (AS) is a neurodevelopmental disorder caused by deficits in maternally inherited <i>UBE3A</i>. The disease is characterized by intellectual disability, impaired motor skills, and behavioral deficits, including increased anxiety and autism spectrum disorder features. The...

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Bibliographic Details
Main Authors: Linn Amanda Syding, Agnieszka Kubik-Zahorodna, Petr Nickl, Vendula Novosadova, Jana Kopkanova, Petr Kasparek, Jan Prochazka, Radislav Sedlacek
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
Angelman syndrome
UBE3A
mouse model
neurodevelopmental disease
autism spectrum disorder
Online Access:https://www.mdpi.com/2073-4409/11/18/2815

Internet

https://www.mdpi.com/2073-4409/11/18/2815

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