Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3

Structural basis for PRC2 decoding of active histone methylation marks H3K36me2/3

Repression of genes by Polycomb requires that PRC2 modifies their chromatin by trimethylating lysine 27 on histone H3 (H3K27me3). At transcriptionally active genes, di- and tri-methylated H3K36 inhibit PRC2. Here, the cryo-EM structure of PRC2 on dinucleosomes reveals how binding of its catalytic su...

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Bibliographic Details
Main Authors: Ksenia Finogenova, Jacques Bonnet, Simon Poepsel, Ingmar B Schäfer, Katja Finkl, Katharina Schmid, Claudia Litz, Mike Strauss, Christian Benda, Jürg Müller
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-11-01
Series:eLife
Subjects:
polycomb repressive complex 2
nucleosome
H3K36me2/3
Drosophila
cryo-EM
histone
Online Access:https://elifesciences.org/articles/61964

Internet

https://elifesciences.org/articles/61964

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