Impact of proton therapy on the DNA damage induction and repair in hematopoietic stem and progenitor cells

Abstract Proton therapy is of great interest to pediatric cancer patients because of its optimal depth dose distribution. In view of healthy tissue damage and the increased risk of secondary cancers, we investigated DNA damage induction and repair of radiosensitive hematopoietic stem and progenitor...

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Bibliographic Details
Main Authors: Simon Sioen, Oniecha Vanhove, Barbara Vanderstraeten, Carlos De Wagter, Monique Engelbrecht, Charlot Vandevoorde, Evan De Kock, Marc-Jan Van Goethem, Anne Vral, Ans Baeyens
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-42362-0