Maslinic Acid Induces Mitochondrial Apoptosis and Suppresses HIF-1α Expression in A549 Lung Cancer Cells under Normoxic and Hypoxic Conditions

Maslinic Acid Induces Mitochondrial Apoptosis and Suppresses HIF-1α Expression in A549 Lung Cancer Cells under Normoxic and Hypoxic Conditions

The apoptotic effects of maslinic acid (MA) at 4, 8, 16, 32 and 64 μmol/L on human lung cancer A549 cells under normoxic and hypoxic conditions were examined. MA at 4–64 and 16–64 μmol/L lowered Bcl-2 expression under normoxic and hypoxic conditions, respectively (p < 0.05). This agent at 4–6...

Full description

Bibliographic Details
Main Authors: Te-Chun Hsia, Wen-Hu Liu, Wen-Wei Qiu, Jian Luo, Mei-Chin Yin
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
maslinic acid
lung cancer
HIF-1α
mitochondrial apoptosis
Online Access:http://www.mdpi.com/1420-3049/19/12/19892

Internet

http://www.mdpi.com/1420-3049/19/12/19892

Similar Items