A Case Study on Integrating a New Key Event Into an Existing Adverse Outcome Pathway on Oxidative DNA Damage: Challenges and Approaches in a Data-Rich Area

A Case Study on Integrating a New Key Event Into an Existing Adverse Outcome Pathway on Oxidative DNA Damage: Challenges and Approaches in a Data-Rich Area

Adverse outcome pathways (AOPs) synthesize toxicological information to convey and weigh evidence in an accessible format. AOPs are constructed in modules that include key events (KEs) and key event relationships (KERs). This modular structure facilitates AOP expansion and network development. AOP d...

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Bibliographic Details
Main Authors: Elizabeth Huliganga, Francesco Marchetti, Jason M. O’Brien, Vinita Chauhan, Carole L. Yauk
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Toxicology
Subjects:
adverse outcome pathways
reactive oxygen species
DNA damage
genotoxicity
toxicology
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2022.827328/full

Internet

https://www.frontiersin.org/articles/10.3389/ftox.2022.827328/full

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