Comparison of the behavior of CHO cells during cultivation in 24-square deep well microplates and conventional shake flask systems

In biopharmaceutical production, the optimization of cell culture media and supplementation is a vital element of process development. Optimization is usually achieved through the screening of multiple media, feed and feeding strategies. However, most screening is performed in shake flasks, which ma...

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Bibliographic Details
Main Authors: Kirti Chaturvedi, Susan Y. Sun, Thomas O’Brien, Yan J. Liu, James W. Brooks
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Biotechnology Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2215017X14000022