Unique, Specific CART Receptor-Independent Regulatory Mechanism of CART(55-102) Peptide in Spinal Nociceptive Transmission and Its Relation to Dipeptidyl-Peptidase 4 (DDP4)

Unique, Specific CART Receptor-Independent Regulatory Mechanism of CART(55-102) Peptide in Spinal Nociceptive Transmission and Its Relation to Dipeptidyl-Peptidase 4 (DDP4)

Cocaine- and amphetamine-regulated transcript (CART) peptides are involved in several physiological and pathological processes, but their mechanism of action is unrevealed due to the lack of identified receptor(s). We provided evidence for the antihyperalgesic effect of CART(55-102) by inhibiting di...

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Bibliographic Details
Main Authors: Márk Kozsurek, Kornél Király, Klára Gyimesi, Erika Lukácsi, Csaba Fekete, Balázs Gereben, Petra Mohácsik, Zsuzsanna Helyes, Kata Bölcskei, Valéria Tékus, Károly Pap, Edina Szűcs, Sándor Benyhe, Tímea Imre, Pál Szabó, Andrea Gajtkó, Krisztina Holló, Zita Puskár
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
cocaine- and amphetamine-regulated transcript (CART) peptide
dipeptidyl-peptidase-4 (DPP4)
chronic pain
hyperalgesia
allodynia
spinal cord
Online Access:https://www.mdpi.com/1422-0067/24/2/918

Internet

https://www.mdpi.com/1422-0067/24/2/918

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