Noxa and Mcl-1 expression influence the sensitivity to BH3-mimetics that target Bcl-xL in patient-derived glioma stem cells

Noxa and Mcl-1 expression influence the sensitivity to BH3-mimetics that target Bcl-xL in patient-derived glioma stem cells

Abstract The recurrence of Glioblastoma is partly attributed to the highly resistant subpopulation of glioma stem cells. A novel therapeutic approach focuses on restoring apoptotic programs in these cancer stem cells, as they are often deregulated. BH3-mimetics, targeting anti-apoptotic Bcl-2 family...

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Bibliographic Details
Main Authors: Mariana Belén Vera, Olivia Morris-Hanon, Germán Ignacio Nogueiras, Luisina Belén Ripari, Myrian Inés Esquivel, Carolina Perez-Castro, Leonardo Romorini, Gustavo Emilio Sevlever, María Elida Scassa, Guillermo Agustín Videla-Richardson
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-20910-4

Internet

https://doi.org/10.1038/s41598-022-20910-4

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