YAP1-MAML2 fusion in a pediatric NF2-wildtype intraparenchymal brainstem schwannoma

YAP1-MAML2 fusion in a pediatric NF2-wildtype intraparenchymal brainstem schwannoma

Abstract Biallelic inactivation of NF2 represents the primary or sole oncogenic driver event in the vast majority of schwannomas. We report on a four-year-old female who underwent subtotal resection of a right medullary intraparenchymal schwannoma. RNA sequencing revealed an in-frame fusion between...

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Bibliographic Details
Main Authors: Matthias A. Karajannis, Bryan K. Li, Mark M. Souweidane, Benjamin Liechty, JinJuan Yao, Jamal K. Benhamida, Tejus A. Bale, Marc K. Rosenblum
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Acta Neuropathologica Communications
Subjects:
Schwannoma
Pediatric
Mastermind like transcriptional coactivator 2 (MAML2)
Yes1 associated transcriptional regulator (YAP1)
Online Access:https://doi.org/10.1186/s40478-022-01423-7

Internet

https://doi.org/10.1186/s40478-022-01423-7

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