Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1G93A ALS mice

Gene therapy for overexpressing Neuregulin 1 type I in skeletal muscles promotes functional improvement in the SOD1G93A ALS mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder affecting motoneurons (MNs), with no effective treatment currently available. The molecular mechanisms that are involved in MN death are complex and not fully understood, with partial contributions of surrounding glial cells and ske...

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Bibliographic Details
Main Authors: Guillem Mòdol-Caballero, Mireia Herrando-Grabulosa, Belén García-Lareu, Neus Solanes, Sergi Verdés, Rosario Osta, Isaac Francos-Quijorna, Rubèn López-Vales, Ana Cristina Calvo, Assumpció Bosch, Xavier Navarro
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Neurobiology of Disease
Subjects:
Neuregulin 1
ErbB receptors
Motoneuron
Motor function
Amyotrophic lateral sclerosis
Spinal cord
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120300681

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http://www.sciencedirect.com/science/article/pii/S0969996120300681

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