lncRNA XIST inhibition promotes M2 polarization of microglial and aggravates the spinal cord injury via regulating miR-124–3p / IRF1 axis

lncRNA XIST inhibition promotes M2 polarization of microglial and aggravates the spinal cord injury via regulating miR-124–3p / IRF1 axis

Background: Spinal cord injury (SCI) has a high disability rate and mortality rate. Recently, LncRNA XIST has been found to be involved in the regulation of inflammatory responses. Therefore, we aimed to investigate the role of XIST in the occurrence and development of SCI and the specific regulatio...

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Bibliographic Details
Main Authors: Jin Yang, Zhiqiang Gong, Junjie Dong, Hangchuan Bi, Bing Wang, Kaili Du, Chunqiang Zhang, Lingqiang Chen
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Heliyon
Subjects:
lncRNA XIST
Spinal cord injury
Microglia
Polarization
miR-124–3p
IRF1
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023050600

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http://www.sciencedirect.com/science/article/pii/S2405844023050600

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