SMYD4 promotes MYH9 ubiquitination through lysine monomethylation modification to inhibit breast cancer progression

SMYD4 promotes MYH9 ubiquitination through lysine monomethylation modification to inhibit breast cancer progression

Abstract Background Breast cancer is the leading cause of female mortality worldwide. (SET And MYND Domain Containing 4) SMYD4 has been reported to be a tumour suppressor. However, the molecular mechanism of SMYD4 remains unclear. Methods The expression level of SMYD4 in breast cancer cells was dete...

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Bibliographic Details
Main Authors: Jin-Shuo Yang, Jun-Ming Cao, Rui Sun, Xue-Jie Zhou, Zhao-Hui Chen, Bo-Wen Liu, Xiao-Feng Liu, Yue Yu, Xin Wang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Breast Cancer Research
Subjects:
Breast cancer
SMYD4
MYH9
Wnt/βcatenin signaling
Methylation
Ubiquitin
Online Access:https://doi.org/10.1186/s13058-025-01973-3

Internet

https://doi.org/10.1186/s13058-025-01973-3

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