Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation

Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation

Intrinsically disordered proteins/regions (IDPs/IDRs) are proteins or peptide segments that fail to form stable 3-dimensional structures in the absence of partner proteins. They are abundant in eukaryotic proteomes and are often associated with human diseases, but their biological functions have bee...

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Bibliographic Details
Main Authors: Zhengjian Zhang, Zarko Boskovic, Mahmud M Hussain, Wenxin Hu, Carla Inouye, Han-Je Kim, A Katherine Abole, Mary K Doud, Timothy A Lewis, Angela N Koehler, Stuart L Schreiber, Robert Tjian
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
transcription factor
intrinsically disordered proteins/regions
metal oxo complexes
preinitiation complex
conformational isomerization
transcription reinitiation
Online Access:https://elifesciences.org/articles/07777

Internet

https://elifesciences.org/articles/07777

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