An LPAR5-antagonist that reduces nociception and increases pruriception

An LPAR5-antagonist that reduces nociception and increases pruriception

IntroductionThe G-protein coupled receptor LPAR5 plays a prominent role in LPA-mediated pain and itch signaling. In this study we focus on the LPAR5-antagonist compound 3 (cpd3) and its ability to affect pain and itch signaling, both in vitro and in vivo.MethodsNociceptive behavior in wild type mice...

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Bibliographic Details
Main Authors: Jacqueline Langedijk, Erika Ivanna Araya, Amanda Ribeiro Barroso, Dagmar Tolenaars, Marc Nazaré, Hassane Belabed, Jens Schoene, Juliana Geremias Chichorro, Ronald Oude Elferink
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pain Research
Subjects:
compound 3
hyperalgesia
inflammatory pain
itch (pruritus)
LPAR5
nociception
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2022.963174/full

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https://www.frontiersin.org/articles/10.3389/fpain.2022.963174/full

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