Alarmin S100A8 Activates Alveolar Epithelial Cells in the Context of Acute Lung Injury in a TLR4-Dependent Manner

Alveolar epithelial cells (AECs) are an essential part of the respiratory barrier in lungs for gas exchange and protection against pathogens. Damage to AECs occurs during lung injury and PAMPs/DAMPs have been shown to activate AECs. However, their interplay as well as the mechanism of AECs’ activati...

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Bibliographische Detailangaben
Hauptverfasser: Deblina Chakraborty, Stefanie Zenker, Jan Rossaint, Anna Hölscher, Michele Pohlen, Alexander Zarbock, Johannes Roth, Thomas Vogl
Format: Artikel
Sprache:English
Veröffentlicht: Frontiers Media S.A. 2017-11-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
Online Zugang:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01493/full