Whole-genome bisulfite sequencing identifies stage- and subtype-specific DNA methylation signatures in pancreatic cancer

Whole-genome bisulfite sequencing identifies stage- and subtype-specific DNA methylation signatures in pancreatic cancer

Summary: In pancreatic ductal adenocarcinoma (PDAC), no recurrent metastasis-specific mutation has been found, suggesting that epigenetic mechanisms, such as DNA methylation, are the major contributors of late-stage disease progression. Here, we performed the first whole-genome bisulfite sequencing...

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Bibliographic Details
Main Authors: Sarah S. Wang, Madison L. Hall, EunJung Lee, Soon-Chan Kim, Neha Ramesh, Sang Hyub Lee, Jin-Young Jang, Richard J. Bold, Ja-Lok Ku, Chang-Il Hwang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
genomics
Epigenetics
cancer systems biology
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224006357

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http://www.sciencedirect.com/science/article/pii/S2589004224006357

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