Creation of mouse TNFR2-selective agonistic TNF mutants using a phage display technique

Creation of mouse TNFR2-selective agonistic TNF mutants using a phage display technique

Tumor necrosis factor-α (TNF), which is an immuno-modulatory cytokine, has been suggested to cause inflammatory responses as well as protection against tissue dysfunction by binding two types of TNF receptor (TNFR1/TNFR2). However, the physiological effects of TNFR2-specific activation remain unclea...

Full description

Bibliographic Details
Main Authors: Daisuke Ando, Masaki Inoue, Haruhiko Kamada, Shintaro Taki, Takeshi Furuya, Yasuhiro Abe, Kazuya Nagano, Yasuo Tsutsumi, Shin-ichi Tsunoda
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Tumor necrosis factor-α
TNF
TNFR2
Phage display technique
Cytokine
Mutant
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580816300929

Internet

http://www.sciencedirect.com/science/article/pii/S2405580816300929

Similar Items