Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells

Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells

Abstract Background Glioblastoma (GBM) is an aggressive brain cancer associated with poor prognosis, intrinsic heterogeneity, plasticity, and therapy resistance. In some GBMs, cell proliferation is fueled by a transcriptional regulator, repressor element-1 silencing transcription factor (REST). Resu...

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Bibliographic Details
Main Authors: Svetlana B. Panina, Joshua V. Schweer, Qian Zhang, Gaurav Raina, Haley A. Hardtke, Seungjin Kim, Wanjie Yang, Dionicio Siegel, Y. Jessie Zhang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Biology
Subjects:
Glioblastoma (GBM)
Repressor element-1 silencing transcription factor
SCP1 phosphatase
Synergy
Online Access:https://doi.org/10.1186/s12915-024-01879-0

Internet

https://doi.org/10.1186/s12915-024-01879-0

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