Relationship of p53 Mutations to Epidermal Cell Proliferation and Apoptosis in Human UV-Induced Skin Carcinogenesis

Relationship of p53 Mutations to Epidermal Cell Proliferation and Apoptosis in Human UV-Induced Skin Carcinogenesis

Human skin is continually subjected to UV-irradiation with the p53 gene playing a pivotal role in repair of UV-induced DNA damage and apoptosis. Consequently, p53 alterations are early events in human UV-induced skin carcinogenesis. We studied 13 squamous cell carcinomas (SCC), 16 actinic keratoses...

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Bibliographic Details
Main Authors: Janine G. Einspahr, David S. Alberts, James A. Wameke, Paul Bozzo, Jenny Basye, Thomas M. Grogan, Mark A. Nelson, G. Tim Bowden
Format: Article
Language:English
Published: Elsevier 1999-11-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
UV-induced skin carcinogenesis
p53 mutation
p53 overexpression
cell proliferation
apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558699800608

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http://www.sciencedirect.com/science/article/pii/S1476558699800608

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