Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system

Antinociceptive effect of PnTx4(5-5), a peptide from Phoneutria nigriventer spider venom, in rat models and the involvement of glutamatergic system

ABSTRACT Background: The venom of Phoneutria nigriventer spider is a source of numerous bioactive substances, including some toxins active in insects. An example is PnTx4(5-5) that shows a high insecticidal activity and no apparent toxicity to mice, although it inhibited NMDA-evoked currents in ra...

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Bibliographic Details
Main Authors: Camila Franco Batista Oliveira, Daniela Pereira Alves, Bruna Luiza Emerich, Suely Gomes de Figueiredo, Marta do Nascimento Cordeiro, Márcia Helena Borges, Michael Richardson, Adriano Monteiro de Castro Pimenta, Igor Dimitri Gama Duarte, Maria Elena de Lima
Format: Article
Language:English
Published: SciELO
Series:Journal of Venomous Animals and Toxins including Tropical Diseases
Subjects:
spider toxin
Γ-ctenitoxin-Pn1a
PnTx4(5-5)
Phoneutria nigriventer
Antinociception
glutamate
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100316&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992019000100316&lng=en&tlng=en

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