Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death

Novel Insights into Redox-Based Mechanisms for Auranofin-Induced Rapid Cancer Cell Death

Auranofin (Ridaura<sup>®</sup>, AUF) is a gold complex originally approved as an antirheumatic agent that has emerged as a potential candidate for multiple repurposed therapies. The best-studied anticancer mechanism of AUF is the inhibition of thioredoxin reductase (TrxR). However, a num...

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Bibliographic Details
Main Authors: Elie Hatem, Nadine El Banna, Amélie Heneman-Masurel, Dorothée Baïlle, Laurence Vernis, Sylvie Riquier, Marie-Pierre Golinelli-Cohen, Olivier Guittet, Cindy Vallières, Jean-Michel Camadro, Xue Qiu, Niko Hildebrandt, Michel Lepoivre, Meng-Er Huang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
auranofin
oxidative stress
redox regulation
cancer
Online Access:https://www.mdpi.com/2072-6694/14/19/4864

Internet

https://www.mdpi.com/2072-6694/14/19/4864

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