Methylation-based reclassification and risk stratification of skull-base chordomas

Methylation-based reclassification and risk stratification of skull-base chordomas

BackgroundSkull-base chordomas are rare malignant bone cancers originating from the remnant of the notochord. Survival is variable, and clinical or molecular factors cannot reliably predict their outcomes. This study therefore identified epigenetic subtypes that defined new chordoma epigenetic profi...

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Bibliographic Details
Main Authors: Xulei Huo, Tengxian Guo, Ke Wang, Bohan Yao, Da Li, Huan Li, Wei Chen, Liang Wang, Zhen Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
DNA methylation
prognostic biomarker
infiltration immune level
stemness indices
copy number variation
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.960005/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.960005/full

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