Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model

Aggregation-prone GFAP mutation in Alexander disease validated using a zebrafish model

Abstract Background Alexander disease (AxD) is an astrogliopathy that predominantly affects the white matter of the central nervous system (CNS), and is caused by a mutation in the gene encoding the glial fibrillary acidic protein (GFAP), an intermediate filament primarily expressed in astrocytes an...

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Bibliographic Details
Main Authors: So-Hyun Lee, Tai-Seung Nam, Kun-Hee Kim, Jin Hee Kim, Woong Yoon, Suk-Hee Heo, Min Jung Kim, Boo Ahn Shin, Ming-Der Perng, Hyon E. Choy, Jihoon Jo, Myeong-Kyu Kim, Seok-Yong Choi
Format: Article
Language:English
Published: BMC 2017-09-01
Series:BMC Neurology
Subjects:
Alexander disease
Leukodystrophy
Glial fibrillary acidic protein
Rosenthal fibers
Astrocyte
Zebrafish
Online Access:http://link.springer.com/article/10.1186/s12883-017-0938-7

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http://link.springer.com/article/10.1186/s12883-017-0938-7

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