Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa

Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa

Abstract Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the leading cause of inherited blindness, is a group of retinal dystrophies characterized by photoreceptor dysfunction and death. The i...

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Bibliographic Details
Main Authors: Alonso Sánchez-Cruz, Alberto Hernández-Pinto, Concepción Lillo, Carolina Isiegas, Miguel Marchena, Ignacio Lizasoain, Fátima Bosch, Pedro de la Villa, Catalina Hernández-Sánchez, Enrique J. de la Rosa
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04839-0

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https://doi.org/10.1038/s41419-022-04839-0

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