Local H2 release remodels senescence microenvironment for improved repair of injured bone

Abstract The senescence microenvironment, which causes persistent inflammation and loss of intrinsic regenerative abilities, is a main obstacle to effective tissue repair in elderly individuals. In this work, we find that local H2 supply can remodel the senescence microenvironment by anti-inflammati...

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Bibliographic Details
Main Authors: Shengqiang Chen, Yuanman Yu, Songqing Xie, Danna Liang, Wei Shi, Sizhen Chen, Guanglin Li, Wei Tang, Changsheng Liu, Qianjun He
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43618-z