Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway
Canine breast cancer (CBC) is the most common spontaneous tumor in intact female dogs, especially in developing countries. The effective anti-tumor agents or therapies for the clinical treatment of CBC are still in need. Auranofin (AF) is a gold complex that has been attested by FDA for treating hum...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-12-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2021.772687/full |
| _version_ | 1819100963729833984 |
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| author | Zhaoyan Lin Zixiang Lin Ying Zhao Nan Cheng Di Zhang Jiahao Lin Hong Zhang Degui Lin |
| author_facet | Zhaoyan Lin Zixiang Lin Ying Zhao Nan Cheng Di Zhang Jiahao Lin Hong Zhang Degui Lin |
| author_sort | Zhaoyan Lin |
| collection | DOAJ |
| description | Canine breast cancer (CBC) is the most common spontaneous tumor in intact female dogs, especially in developing countries. The effective anti-tumor agents or therapies for the clinical treatment of CBC are still in need. Auranofin (AF) is a gold complex that has been attested by FDA for treating human rheumatism, which has been found as a great anti-tumor agent in recent years. ICG-001 is a small molecule inhibitor of Wnt/β-catenin pathway. In the present study, we demonstrated that a combination of AF and ICG-001 could synergistically suppress the proliferation of CBC in vitro and in vivo. Moreover, the synergistical effect was related with apoptosis caused by mitochondrial damage and ROS production. In conclusion, combination of AF and ICG-001 could synergistically suppress the growth of CBC in vitro and in vivo by leading apoptosis via mitochondrial signaling pathway and might provide a novel potential choice for the clinical treatment of CBC. |
| first_indexed | 2024-12-22T01:11:08Z |
| format | Article |
| id | doaj.art-b5acb58264234728b792cd2cf8d5c5f5 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-12-22T01:11:08Z |
| publishDate | 2021-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-b5acb58264234728b792cd2cf8d5c5f52022-12-21T18:43:58ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692021-12-01810.3389/fvets.2021.772687772687Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial PathwayZhaoyan Lin0Zixiang Lin1Ying Zhao2Nan Cheng3Di Zhang4Jiahao Lin5Hong Zhang6Degui Lin7Department of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaCollege of Animal Science and Technology, Hainan University, Haikou, ChinaDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, China Agricultural University, Beijing, ChinaCanine breast cancer (CBC) is the most common spontaneous tumor in intact female dogs, especially in developing countries. The effective anti-tumor agents or therapies for the clinical treatment of CBC are still in need. Auranofin (AF) is a gold complex that has been attested by FDA for treating human rheumatism, which has been found as a great anti-tumor agent in recent years. ICG-001 is a small molecule inhibitor of Wnt/β-catenin pathway. In the present study, we demonstrated that a combination of AF and ICG-001 could synergistically suppress the proliferation of CBC in vitro and in vivo. Moreover, the synergistical effect was related with apoptosis caused by mitochondrial damage and ROS production. In conclusion, combination of AF and ICG-001 could synergistically suppress the growth of CBC in vitro and in vivo by leading apoptosis via mitochondrial signaling pathway and might provide a novel potential choice for the clinical treatment of CBC.https://www.frontiersin.org/articles/10.3389/fvets.2021.772687/fullauranofinICG-001mitochondrial pathwayROSCBC |
| spellingShingle | Zhaoyan Lin Zixiang Lin Ying Zhao Nan Cheng Di Zhang Jiahao Lin Hong Zhang Degui Lin Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway Frontiers in Veterinary Science auranofin ICG-001 mitochondrial pathway ROS CBC |
| title | Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway |
| title_full | Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway |
| title_fullStr | Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway |
| title_full_unstemmed | Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway |
| title_short | Auranofin and ICG-001 Emerge Synergistic Anti-tumor Effect on Canine Breast Cancer by Inducing Apoptosis via Mitochondrial Pathway |
| title_sort | auranofin and icg 001 emerge synergistic anti tumor effect on canine breast cancer by inducing apoptosis via mitochondrial pathway |
| topic | auranofin ICG-001 mitochondrial pathway ROS CBC |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2021.772687/full |
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