Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma

Antitumor Activities and Cellular Changes Induced by TrkB Inhibition in Medulloblastoma

Neurotrophins are critically involved in regulating normal neural development and plasticity. Brain-derived neurotrophic factor (BDNF), a neurotrophin that acts by binding to the tropomyosin receptor kinase B (TrkB) receptor, has also been implicated in the progression of several types of cancer. Ho...

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Bibliographic Details
Main Authors: Amanda Thomaz, Kelly de Vargas Pinheiro, Bárbara Kunzler Souza, Lauro Gregianin, Algemir L. Brunetto, André T. Brunetto, Caroline Brunetto de Farias, Mariane da Cunha Jaeger, Vijay Ramaswamy, Carolina Nör, Michael D. Taylor, Rafael Roesler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
brain-derived neurotrophic factor
tropomyosin receptor kinase B
neurotrophin
medulloblastoma
brain tumor
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00698/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00698/full

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