Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation.

Neurons require a nearly constant supply of ATP. Glucose is the predominant source of brain ATP, but the direct effects of prolonged glucose deprivation on neuronal viability and function remain unclear. In sparse rat hippocampal microcultures, neurons were surprisingly resilient to 16 h glucose rem...

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Bibliographic Details
Main Authors: Courtney Sobieski, Natasha Warikoo, Hong-Jin Shu, Steven Mennerick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5884621?pdf=render