In silico screening of Andrographis paniculata secondary metabolites as anti-diabetes mellitus through PDE9 inhibition

In silico screening of Andrographis paniculata secondary metabolites as anti-diabetes mellitus through PDE9 inhibition

Background and purpose: Andrographis paniculata (AP) has long been used as an anti-diabetic agent, but the mechanism of action and active substance responsible for the anti-diabetic effect, particularly by inhibiting phosphodiesterase-9 (PDE9), which is one of the targets of anti-diabetic medication...

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Bibliographic Details
Main Authors: Netty Ino Ischak, La Aman Ode, Hamsidar Hasan, Akram La Kilo, Aiyi Asnawi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Research in Pharmaceutical Sciences
Subjects:
andrographis paniculate; anti-diabetic; molecular docking; molecular dynamics
pde9; secondary metabolites.
Online Access:http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2023;volume=18;issue=1;spage=100;epage=111;aulast=Ischak

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http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2023;volume=18;issue=1;spage=100;epage=111;aulast=Ischak

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