Arsenic Activates the ER Stress-Associated Unfolded Protein Response via the Activating Transcription Factor 6 in Human Bronchial Epithelial Cells

Arsenic Activates the ER Stress-Associated Unfolded Protein Response via the Activating Transcription Factor 6 in Human Bronchial Epithelial Cells

Arsenic is a well-known human carcinogen associated with a number of cancers, including lung cancers. We have previously shown that long-term exposure to an environmentally relevant concentration of inorganic arsenic (As<sup>3+</sup>) leads to the malignant transformation of the BEAS2B c...

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Bibliographic Details
Main Authors: Priya Wadgaonkar, Zhuoyue Bi, Junmei Wan, Yao Fu, Qian Zhang, Bandar Almutairy, Wenxuan Zhang, Yiran Qiu, Chitra Thakur, Maik Hüttemann, Fei Chen
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Biomedicines
Subjects:
arsenic
ER stress
UPR
metabolism
ATF6
Nrf2
Online Access:https://www.mdpi.com/2227-9059/10/5/967

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https://www.mdpi.com/2227-9059/10/5/967

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