Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory

Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory

Hippocampal hyperactivity, ascribed to amyloid β (Aβ)-induced imbalances in neural excitation and inhibition, is found in patients with mild cognitive impairment, a prodromal stage of Alzheimer's disease (AD). To better understand the relationship between hippocampal hyperactivity and the molec...

Full description

Bibliographic Details
Main Authors: Misato Yoshikawa, Yoshiyuki Soeda, Makoto Michikawa, Osborne F. X. Almeida, Akihiko Takashima
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Neuroscience
Subjects:
tau
amyloid beta-peptides
hippocampus
hyperexcitation
Dementia
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00124/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2018.00124/full

Similar Items