CD19 CAR-NK CONSTRUCTION WITH A NEW HINGE AND GITRL CO-EXPRESSION FOR TREG ACTIVITY INHIBITION

Introduction: Chimeric Antigen Receptor T (CAR-T) cell therapy has emerged as a promising approach in which autologous T cells are engineered to recognize a specific target. Although the clinical responses are encouraging, nearly 60% of large B cell lymphoma patients have disease progression after a...

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Bibliographic Details
Main Authors: DF Schmidt, S Ebrahimabadi, MC Tirapelle, DT Covas, V Picanço-Castro
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Hematology, Transfusion and Cell Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2531137923011835