Kappa-Opioid Agonist U50,488H-Mediated Protection Against Heart Failure Following Myocardial Ischemia/Reperfusion: Dual Roles of Heme Oxygenase-1

Kappa-Opioid Agonist U50,488H-Mediated Protection Against Heart Failure Following Myocardial Ischemia/Reperfusion: Dual Roles of Heme Oxygenase-1

Backgrounds/Aims: The selective κ-opioid agonist U50,488H protects heart from myocardial ischemia-reperfusion (MI/R) injury. We examined whether U50,488H is also beneficial for MI/R induced heart failure. Methods: Anesthetized male Sprague-Dawley rats were subjected to 30 min of myocardia...

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Bibliographic Details
Main Authors: Guang Tong, Ben Zhang, Xuan Zhou, Jinbo Zhao, Zhongchan Sun, Ye Tao, Jianming Pei, Weida Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Myocardial ischemia/reperfusion
Heart failure
κ-opioid
Heme oxygenase-1
Online Access:http://www.karger.com/Article/FullText/447911

Internet

http://www.karger.com/Article/FullText/447911

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