Phillyrin Prevents Neuroinflammation-Induced Blood–Brain Barrier Damage Following Traumatic Brain Injury via Altering Microglial Polarization

Phillyrin Prevents Neuroinflammation-Induced Blood–Brain Barrier Damage Following Traumatic Brain Injury via Altering Microglial Polarization

Background: Phillyrin (Phi) is the main polyphenolic compound found in Forsythia suspensa. Recent studies have revealed that Phi has potent antioxidative and anti-inflammatory effects. However, whether Phi could relieve blood–brain barrier (BBB) damage following traumatic brain injury (TBI) remains...

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Bibliographic Details
Main Authors: Qian Jiang, Ding Wei, Xuejun He, Chao Gan, Xiaobing Long, Huaqiu Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
traumatic brain injury
phillyrin
microglia
PPARγ
neuroinflammation
blood–brain barrier
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.719823/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.719823/full

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